Wednesday 27 November 2019

Dihydromyricetin’s Background

Dihydromyricetin is found in the Hovenia dulcis tree, also known as the Oriental Raisin Tree; the leaves of the tree have been brewed as a tea in the Near East for centuries, and in 2008 was approved by the Korean FDA for use as a treatment for alcoholism.  Dihydromyricetin has also been shown to be effective in treating oral ulcers [2], and antioxidant properties [4].

Dihydromyricetin Mechanism of Action
Dihydromyricetin appears to have two Mechanisms of Action that allow it to accomplish its two main benefits: the anti-oxidative effects of dihydromyricetin appear to be due to its ability to remove Fe and Fe2+ ions from the body; both Fe and Fe2+ are heavy metals that can have negative effects on the body when present in higher amounts [4]. The second mechanism of action for dihydromyricetin is acting as an antagonist for the GABA(A) receptors in the brain; these receptors are potentiated when a person is in a state of acute alcohol consumption.  On a related note, dihydromyricetin also has been found to improve GABA(A) receptor plasticity in alcohol withdrawal and tolerance [6,13].
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